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phenobarbital will lessen the level or impact of diazepam buccal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Robust or reasonable CYP3A4 inducers may raise level of diazepam elimination; consequently, efficacy of diazepam may very well be reduced.Avoid; coadministration with CYP3A inducers may lead to reduced plas